Medellin to Panama City (MDE-PTY): nonstop flights and who flies them

Copa Airlines flies nonstop between Medellin (MDE) and Panama City (PTY), roughly 54 times a week. With Copa Airlines running most of the schedule, the shape of a week is predictable, which makes an open premium seat on a given date easy to spot and quick to lose. Copa Airlines fly the route nonstop in 2LNR's schedule data; the timetable and the reverse direction are below.

Schedule last confirmed . Departure times come from 2LNR's schedule data; confirm with the airline before you book.

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54
Nonstop flights a week
337 mi
Nonstop distance
Free
To get started

Medellin to Panama City flight schedule

Scheduled nonstop departures for MDE to PTY, last checked against our schedule feed on September 6, 2026. Airlines retime and cancel flights, so confirm with the airline before you book.

Schedule data dated .

Scheduled nonstop departures from Medellin (MDE) to Panama City (PTY)
Date Flight Airline Departs MDE Arrives PTY Duration Aircraft
CM 151Copa Airlines05:0006:291h 29m738
CM 209Copa Airlines06:2507:541h 29m738
CM 398Copa Airlines09:1510:441h 29m7M9
CM 757Copa Airlines10:3512:041h 29m738
CM 687Copa Airlines12:4014:091h 29m738
CM 154Copa Airlines15:1016:391h 29m738
CM 766Copa Airlines16:3017:591h 29m738
CM 157Copa Airlines18:2019:491h 29m738
CM 151Copa Airlines05:0006:291h 29m7M8
CM 209Copa Airlines06:2507:541h 29m738
CM 164Copa Airlines08:3510:041h 29m738
CM 398Copa Airlines09:1510:441h 29m7M9
CM 687Copa Airlines12:4014:091h 29m738
CM 154Copa Airlines15:1016:391h 29m738
CM 157Copa Airlines18:2019:491h 29m738
CM 151Copa Airlines05:0006:291h 29m738
CM 209Copa Airlines06:2507:541h 29m738
CM 398Copa Airlines09:1510:441h 29m7M9
CM 687Copa Airlines12:4014:091h 29m7M9
CM 154Copa Airlines15:1016:391h 29m738
CM 157Copa Airlines18:2019:491h 29m738
CM 151Copa Airlines05:0006:291h 29m738
CM 209Copa Airlines06:2507:541h 29m73G
CM 164Copa Airlines08:3510:041h 29m738
CM 398Copa Airlines09:1510:441h 29m7M9
CM 757Copa Airlines10:3512:041h 29m7M9
CM 687Copa Airlines12:4014:091h 29m7M9
CM 154Copa Airlines15:1016:391h 29m738
CM 766Copa Airlines16:3017:591h 29m738
CM 157Copa Airlines18:2019:491h 29m738
CM 151Copa Airlines05:0006:291h 29m738
CM 209Copa Airlines06:2507:541h 29m738
CM 398Copa Airlines09:1510:441h 29m7M9
CM 687Copa Airlines12:4014:091h 29m738
CM 154Copa Airlines15:1016:391h 29m738
CM 157Copa Airlines18:2019:491h 29m738
CM 151Copa Airlines05:0006:291h 29m7M8
CM 209Copa Airlines06:2507:541h 29m73G
CM 164Copa Airlines08:3510:041h 29m738
CM 398Copa Airlines09:1510:441h 29m7M9

Showing the first 40 of 53 scheduled MDE to PTY departures across the next 7 days with service. Every remaining date is on the interactive map.

Departure and arrival times are local at their own airport, so an arrival can fall on a different local date than the departure; the duration column is the true elapsed flying time. A dash means the airline has not filed that value in the schedule data we hold. Aircraft are IATA equipment codes as filed, and can change up to departure.

See every MDE to PTY date on the interactive map

The full MDE to PTY nonstop schedule

Copa Airlines fly the route nonstop in 2LNR's schedule data. This page carries the full MDE to PTY nonstop schedule, who operates each departure and how often it runs; the reverse direction is linked below.

See real availability

Confirmed upgrade and award seats on each MDE to PTY departure, checked against live inventory so you know what is open before you book.

Set an alert

Premium inventory turns over fast. Watch this route and 2LNR notifies you when space appears on a date you are tracking.

Plan on the map

See MDE to PTY on the interactive route map, with schedules, connections, and route statistics.

Airlines flying Medellin to Panama City nonstop

Carriers operating MDE to PTY nonstop in the current schedule. 2LNR tracks confirmed upgrade and award space on each of them.

See MDE to PTY on the interactive map →

Frequently asked questions about MDE to PTY

How far is Panama City from Medellin?
MDE to PTY covers about 337 miles nonstop. Flight times vary by aircraft and season; the schedule table on this page lists each scheduled departure with its own times.
Which airlines fly nonstop from MDE to PTY?
Copa Airlines is currently the only airline flying MDE to PTY nonstop. None of them is a carrier 2LNR reads inventory for, so this page carries the MDE to PTY schedule rather than a space claim.
How many flights a week are there from MDE to PTY?
About 54 nonstop flights a week run between Medellin and Panama City in the current schedule, operated by Copa Airlines. Frequency shifts by season, and the schedule table on this page shows what is scheduled next.
What time do flights from MDE to PTY depart?
Scheduled MDE to PTY nonstops in the next 7 days with service leave between 05:00 and 18:20, local time at Medellin. The schedule table on this page lists every departure by date, with its arrival time and aircraft.
Does 2LNR show upgrade or award space on MDE to PTY?
Not on this route: none of Copa Airlines is a carrier 2LNR reads inventory for. The page carries the full MDE to PTY nonstop schedule and who flies each departure, and the reverse direction is linked below.

See the full MDE to PTY nonstop schedule

Every scheduled departure on this route, with who flies it. On the routes 2LNR does read inventory for, upgrade and award space shows by date, the next 14 days free on every product and the full horizon on Pro.

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