Panama City to Medellin (PTY-MDE): nonstop flights and who flies them

Copa Airlines flies nonstop between Panama City (PTY) and Medellin (MDE), roughly 54 times a week. With Copa Airlines running most of the schedule, the shape of a week is predictable, which makes an open premium seat on a given date easy to spot and quick to lose. Copa Airlines fly the route nonstop in 2LNR's schedule data; the timetable and the reverse direction are below.

Schedule last confirmed . Departure times come from 2LNR's schedule data; confirm with the airline before you book.

See PTY to MDE on the interactive map Get started free
54
Nonstop flights a week
337 mi
Nonstop distance
Free
To get started

Panama City to Medellin flight schedule

Scheduled nonstop departures for PTY to MDE, last checked against our schedule feed on September 6, 2026. Airlines retime and cancel flights, so confirm with the airline before you book.

Schedule data dated .

Scheduled nonstop departures from Panama City (PTY) to Medellin (MDE)
Date Flight Airline Departs PTY Arrives MDE Duration Aircraft
CM 150Copa Airlines06:5008:151h 25m7M9
CM 756Copa Airlines08:1509:401h 25m738
CM 397Copa Airlines09:3010:551h 25m738
CM 654Copa Airlines12:5014:151h 25m738
CM 764Copa Airlines13:2014:451h 25m738
CM 156Copa Airlines15:3016:551h 25m738
CM 208Copa Airlines18:3019:551h 25m7M8
CM 163Copa Airlines19:1020:351h 25m738
CM 155Copa Airlines21:2522:501h 25m738
CM 150Copa Airlines06:5008:151h 25m7M9
CM 397Copa Airlines09:3010:551h 25m738
CM 654Copa Airlines12:5014:151h 25m738
CM 156Copa Airlines15:3016:551h 25m738
CM 208Copa Airlines18:3019:551h 25m7M8
CM 155Copa Airlines21:2522:501h 25m73G
CM 150Copa Airlines06:5008:151h 25m7M9
CM 397Copa Airlines09:3010:551h 25m738
CM 654Copa Airlines12:5014:151h 25m738
CM 156Copa Airlines15:3016:551h 25m738
CM 208Copa Airlines18:3019:551h 25m7M8
CM 163Copa Airlines19:1020:351h 25m738
CM 155Copa Airlines21:2522:501h 25m73G
CM 150Copa Airlines06:5008:151h 25m7M9
CM 756Copa Airlines08:1509:401h 25m7M9
CM 397Copa Airlines09:3010:551h 25m738
CM 654Copa Airlines12:5014:151h 25m738
CM 764Copa Airlines13:2014:451h 25m738
CM 156Copa Airlines15:3016:551h 25m738
CM 208Copa Airlines18:3019:551h 25m7M8
CM 155Copa Airlines21:2522:501h 25m73G
CM 150Copa Airlines06:5008:151h 25m7M9
CM 397Copa Airlines09:3010:551h 25m738
CM 654Copa Airlines12:5014:151h 25m738
CM 156Copa Airlines15:3016:551h 25m738
CM 208Copa Airlines18:3019:551h 25m7M8
CM 163Copa Airlines19:1020:351h 25m738
CM 155Copa Airlines21:2522:501h 25m73G
CM 150Copa Airlines06:5008:151h 25m7M9
CM 756Copa Airlines08:1509:401h 25m7M9
CM 397Copa Airlines09:3010:551h 25m738

Showing the first 40 of 53 scheduled PTY to MDE departures across the next 7 days with service. Every remaining date is on the interactive map.

Departure and arrival times are local at their own airport, so an arrival can fall on a different local date than the departure; the duration column is the true elapsed flying time. A dash means the airline has not filed that value in the schedule data we hold. Aircraft are IATA equipment codes as filed, and can change up to departure.

See every PTY to MDE date on the interactive map

The full PTY to MDE nonstop schedule

Copa Airlines fly the route nonstop in 2LNR's schedule data. This page carries the full PTY to MDE nonstop schedule, who operates each departure and how often it runs; the reverse direction is linked below.

See real availability

Confirmed upgrade and award seats on each PTY to MDE departure, checked against live inventory so you know what is open before you book.

Set an alert

Premium inventory turns over fast. Watch this route and 2LNR notifies you when space appears on a date you are tracking.

Plan on the map

See PTY to MDE on the interactive route map, with schedules, connections, and route statistics.

Airlines flying Panama City to Medellin nonstop

Carriers operating PTY to MDE nonstop in the current schedule. 2LNR tracks confirmed upgrade and award space on each of them.

See PTY to MDE on the interactive map →

Frequently asked questions about PTY to MDE

How far is Medellin from Panama City?
PTY to MDE covers about 337 miles nonstop. Flight times vary by aircraft and season; the schedule table on this page lists each scheduled departure with its own times.
Which airlines fly nonstop from PTY to MDE?
Copa Airlines is currently the only airline flying PTY to MDE nonstop. None of them is a carrier 2LNR reads inventory for, so this page carries the PTY to MDE schedule rather than a space claim.
How many flights a week are there from PTY to MDE?
About 54 nonstop flights a week run between Panama City and Medellin in the current schedule, operated by Copa Airlines. Frequency shifts by season, and the schedule table on this page shows what is scheduled next.
What time do flights from PTY to MDE depart?
Scheduled PTY to MDE nonstops in the next 7 days with service leave between 06:50 and 21:25, local time at Panama City. The schedule table on this page lists every departure by date, with its arrival time and aircraft.
Does 2LNR show upgrade or award space on PTY to MDE?
Not on this route: none of Copa Airlines is a carrier 2LNR reads inventory for. The page carries the full PTY to MDE nonstop schedule and who flies each departure, and the reverse direction is linked below.

See the full PTY to MDE nonstop schedule

Every scheduled departure on this route, with who flies it. On the routes 2LNR does read inventory for, upgrade and award space shows by date, the next 14 days free on every product and the full horizon on Pro.

Get started free