Medellin to Guayaquil (MDE-GYE): nonstop flights and who flies them

Avianca flies nonstop from Medellin (MDE) to Guayaquil (GYE) just three times a week. With so few departures, each one carries the only premium seats on the route that day. Avianca fly the route nonstop in 2LNR's schedule data; the timetable and the reverse direction are below.

Schedule last confirmed September 6, 2026. Departure times come from 2LNR's schedule data; confirm with the airline before you book.

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Nonstop flights a week

651 mi

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Medellin to Guayaquil flight schedule

Scheduled nonstop departures for MDE to GYE, last checked against our schedule feed on September 6, 2026. Airlines retime and cancel flights, so confirm with the airline before you book.

Scheduled nonstop departures from Medellin (MDE) to Guayaquil (GYE)
Date	Flight	Airline	Departs MDE	Arrives GYE	Duration	Aircraft
Wed, Sep 9	AV 8399	Avianca	16:50	18:50	2h	320
Fri, Sep 11	AV 8399	Avianca	16:50	18:50	2h	320
Mon, Sep 14	AV 8399	Avianca	16:50	18:50	2h	320
Wed, Sep 16	AV 8399	Avianca	16:50	18:50	2h	320
Fri, Sep 18	AV 8399	Avianca	16:50	18:50	2h	320
Mon, Sep 21	AV 8399	Avianca	16:50	18:50	2h	320
Wed, Sep 23	AV 8399	Avianca	16:50	18:50	2h	320

Showing all 7 scheduled MDE to GYE departures across the next 7 days with service. Later dates are on the interactive map.

Departure and arrival times are local at their own airport, so an arrival can fall on a different local date than the departure; the duration column is the true elapsed flying time. A dash means the airline has not filed that value in the schedule data we hold. Aircraft are IATA equipment codes as filed, and can change up to departure.

See every MDE to GYE date on the interactive map

The full MDE to GYE nonstop schedule

Avianca fly the route nonstop in 2LNR's schedule data. This page carries the full MDE to GYE nonstop schedule, who operates each departure and how often it runs; the reverse direction is linked below.

See real availability

Confirmed upgrade and award seats on each MDE to GYE departure, checked against live inventory so you know what is open before you book.

Set an alert

Premium inventory turns over fast. Watch this route and 2LNR notifies you when space appears on a date you are tracking.

Plan on the map

See MDE to GYE on the interactive route map, with schedules, connections, and route statistics.

Airlines flying Medellin to Guayaquil nonstop

Carriers operating MDE to GYE nonstop in the current schedule. 2LNR tracks confirmed upgrade and award space on each of them.

Avianca (AV) route map

See MDE to GYE on the interactive map →

Frequently asked questions about MDE to GYE

How far is Guayaquil from Medellin?

MDE to GYE covers about 651 miles nonstop. Flight times vary by aircraft and season; the schedule table on this page lists each scheduled departure with its own times.

Which airlines fly nonstop from MDE to GYE?

Avianca is currently the only airline flying MDE to GYE nonstop. None of them is a carrier 2LNR reads inventory for, so this page carries the MDE to GYE schedule rather than a space claim.

How often does MDE to GYE operate?

The nonstop currently runs three times a week, on Avianca. Thin schedules like this change by season, and an alert will catch anything added.

What time do flights from MDE to GYE depart?

In the next 7 days with service, every scheduled MDE to GYE nonstop leaves at 16:50 local time at Medellin. The schedule table on this page lists each departure by date.

Does 2LNR show upgrade or award space on MDE to GYE?

Not on this route: none of Avianca is a carrier 2LNR reads inventory for. The page carries the full MDE to GYE nonstop schedule and who flies each departure, and the reverse direction is linked below.

See the full MDE to GYE nonstop schedule

Every scheduled departure on this route, with who flies it. On the routes 2LNR does read inventory for, upgrade and award space shows by date, the next 14 days free on every product and the full horizon on Pro.

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